{"id":3179,"date":"2023-09-12T12:40:45","date_gmt":"2023-09-12T10:40:45","guid":{"rendered":"https:\/\/dermaclub.it\/photodynamic-therapy-in-dermatology\/"},"modified":"2024-09-23T14:48:35","modified_gmt":"2024-09-23T12:48:35","slug":"photodynamic-therapy-in-dermatology","status":"publish","type":"post","link":"https:\/\/dermaclub.it\/en\/dermatology-fact-sheets\/photodynamic-therapy-in-dermatology\/","title":{"rendered":"Photodynamic therapy in dermatology"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]Photodynamic therapy is a dermatologic treatment for various pathological or cosmetic conditions affecting the skin, including: acne, lesions due to photodamage or skin aging, actinic or solar keratoses, pre-tumor lesions, and cancerous lesions. <br \/>Photodynamic therapy is based on light energy and the application of a photosensitizing substance in the form of a cream. When applied to the skin, the cream triggers an oxidative reaction only in pathological epidermal cells, resulting in their elimination and prompting their replacement with new cells.<br \/>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indice<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/dermaclub.it\/en\/dermatology-fact-sheets\/photodynamic-therapy-in-dermatology\/#What_is_it_and_what_is_it_used_for\" >What is it and what is it used for?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/dermaclub.it\/en\/dermatology-fact-sheets\/photodynamic-therapy-in-dermatology\/#Which_conditions_could_benefit_from_photodynamic_therapy\" >Which conditions could benefit from photodynamic therapy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/dermaclub.it\/en\/dermatology-fact-sheets\/photodynamic-therapy-in-dermatology\/#How_does_it_work\" >How does it work?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/dermaclub.it\/en\/dermatology-fact-sheets\/photodynamic-therapy-in-dermatology\/#Pros_and_cons_of_photodynamic_therapy\" >Pros and cons of photodynamic therapy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/dermaclub.it\/en\/dermatology-fact-sheets\/photodynamic-therapy-in-dermatology\/#Who_can_have_photodynamic_therapy\" >Who can have photodynamic therapy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/dermaclub.it\/en\/dermatology-fact-sheets\/photodynamic-therapy-in-dermatology\/#Preparation_for_treatment\" >Preparation for treatment<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/dermaclub.it\/en\/dermatology-fact-sheets\/photodynamic-therapy-in-dermatology\/#Post_treatment_care\" >Post treatment care<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_is_it_and_what_is_it_used_for\"><\/span><b>What is it and what is it used for?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Photodynamic therapy is the treatment of choice for solar or actinic keratoses and, in general, for all photoinduced lesions (induced by the sun or UV lamps), including solar aging. For the treatment of various oncological or aesthetic conditions, photodynamic therapy uses irradiation on small areas of skin. <br \/>Photodynamic therapy has many other valid applications especially in inflammatory diseases where it can help inflammation disappear. <br \/>In the field of oncology , for which the therapy originated, it can be used to treat pre-tumor and tumor lesions, in cases of basal cell carcinoma or squamous cell carcinoma (Bowen&#8217;s disease).<br \/>The effectiveness of the therapy has made it a reference for the treatment of other skin pathological conditions.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Which_conditions_could_benefit_from_photodynamic_therapy\"><\/span><b>Which conditions could benefit from photodynamic therapy?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]The main applications of photodynamic therapy in dermatology are for cases of: <\/p>\n<ul>\n<li>Actinic Keratoses<\/li>\n<li>Superficial basal cell carcinoma<\/li>\n<li>Bowen&#8217;s disease<\/li>\n<li>Actinic porokeratosis\/ porokeratosis of Mibelli<\/li>\n<li>Morphea in active phase<\/li>\n<li>Lipoid necrobiosis<\/li>\n<li>Ulcers and bedsores<\/li>\n<li>Acne (teen and adult)<\/li>\n<li>Photoaging<\/li>\n<li>Lichen Planus<\/li>\n<li>Lichen sclerosus (active phase)<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_does_it_work\"><\/span><b>How does it work?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Photodynamic therapy consists of applying an aminolevulinic acid (ALA)-based cream to the lesion. The area of application is immediately covered with a bandage to allow the substance to be rapidly absorbed and for it to reach the damaged cells. The molecule used within the cream interacts exclusively with the most unstable or damaged cells by triggering an oxidative reaction that activates upon illumination with red light (630 nm) from an LED source. The photodynamic reaction is so active that it can eliminate both cancer cells and cells damaged by inflammation.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Pros_and_cons_of_photodynamic_therapy\"><\/span><b>Pros and cons of photodynamic therapy<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The dermatologist will be able to evaluate the benefits and possible risks of treatment. Photodynamic therapy is effective in treating many conditions and has a low risk of side effects, compared to other treatments that have a greater impact on the body. <\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoids surgery or use of drugs with possible side effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Can treat a large area of skin in a single session<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It\u2019s important to note that, while minimal, side effects include the reddening of the skin at the treatment site that may last from a few days to up to one week. This may be accompanied by an initial sensation of heat\/burning upon exposure to LED light, however this can be remedied by cooling from outside the skin.<\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Who_can_have_photodynamic_therapy\"><\/span><b>Who can have photodynamic therapy?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Photodynamic therapy is generally effective and tolerated by all individuals.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It may also be used on patients with photosensitivity, porphyria or xeroderma pigmentosum; and in those who have received retinoic acid treatment in the previous month.<\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Preparation_for_treatment\"><\/span><b>Preparation for treatment<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Patients should avoid the use of cosmetics, makeup, lotions, creams and deodorants on the affected area for the three days before treatment.<br \/>Immediately ahead of treatment, aminolevulinic acid cream is applied to the area, which is then quickly bandaged. Once this is completed, the patient must wait for about two hours to allow the cream to penetrate the skin and interact with the damaged cells. During this period, the patient should not engage in any physical activity and should not be exposed to the sun.<br \/>The following red light exposure takes between six and ten minutes depending on the LED lamps used.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Post_treatment_care\"><\/span><b>Post treatment care<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]At the end of the photodynamic treatment, the dermatologist will apply restorative ointment or <a href=\"https:\/\/mostskincare.com\/negozio\/linea-prodotti-dermatologica\/peg-unguento-2\/\" target=\"_blank\" rel=\"noopener\"><strong>PEG Ointment<\/strong><\/a>. The same ointment should be applied by the patient at home in the evening until any reactions or side effects from photodynamic therapy have subsided and the skin has returned to normal. During this period, the skin should be cleaned only with water, and all facial treatments, creams and make-ups must be suspended until the skin has fully repaired. <br \/>Should it be necessary, there is no limit to the number of phototherapy treatments a person can undergo. <br \/>For further reading, see also:<br \/>https:\/\/dermaclub.it\/malattie-della-pelle\/vincere-lacne-senza-farmaci-e-possibilehttps:\/\/dermaclub.it\/schede-dermatologiche\/fotoinvecchiamento\/\/ <br \/>https:\/\/dermaclub.it\/malattie-della-pelle\/cheratosi-solari-o-attiniche-terapie-efficaci-per-contrastare-i-segni-del-sole\/[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text]Photodynamic therapy is a dermatologic treatment for various pathological or cosmetic conditions affecting the skin, including: acne, lesions due to photodamage or skin aging, actinic or<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":2802,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[48],"tags":[],"class_list":["post-3179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dermatology-fact-sheets"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.1 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Photodynamic therapy: from red light the stimulus to heal<\/title>\n<meta name=\"description\" content=\"Photodynamic Therapy exploits the reaction between photosensitizer and light to produce positive antitumor and regeneration-stimulating effects\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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