{"id":3305,"date":"2023-08-09T15:48:58","date_gmt":"2023-08-09T13:48:58","guid":{"rendered":"https:\/\/dermaclub.it\/biological-anticancer-drugs-and-skin-reactions-part-one\/"},"modified":"2026-03-30T15:11:37","modified_gmt":"2026-03-30T13:11:37","slug":"biological-anticancer-drugs-and-skin-reactions-part-one","status":"publish","type":"post","link":"https:\/\/dermaclub.it\/en\/skin-diseases\/biological-anticancer-drugs-and-skin-reactions-part-one\/","title":{"rendered":"Biological anticancer drugs and skin reactions: part one"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]An important modern oncological strategy to defeat cancer is to block certain cellular receptors to inhibit the functions of neoplastic cells. Named targeted therapy, it targets only the specific receptors that it has been designed to block. Targeted therapy differs from chemotherapy, which instead kills all cells regardless if they are cancerous or not.
\nThe receptor for epidermal growth factor (EGFR) is expressed on the surface of cells. The binding between EGFR and extracellular proteins stimulates the activity of intracellular protein tyrosine kinase (TK), which in turn activates cellular functions such as migration, adhesion and proliferation.
\nTherefore, blocking the receptor for EGFR and\/or the activation of tyrosine kinase also prevents many of the most dangerous activities in tumor development which are precisely that of cell migration, adhesion and proliferation.
\nIn recent years, the advanced pharmaceutical industry has produced numerous drugs capable of blocking EGFR or TK. These drugs have proven to be very successful in combating epithelial neoplasms and have thus become part of treatment protocols for many human cancers.
\nSome of these are already marketed, while others will be soon. The most widely used drug names include cetuximab (Erbitux); panitumumab (Vectibix); gefitinib (Iressa), erlotinib (Tarceva); trastuzumab (Herceptin) and iapatinib (Tyverb).
\nHowever, right from the introduction of these targeted therapy drugs, unwanted side effects including cutaneous reactions have been recorded.
\nIl fatto \u00e8 facilmente spiegabile perch\u00e9 l\u2019epidermide \u00e8 un epitelio a rapida riproduzione e va in sofferenza, quando per scopi terapeutici, vengono somministrati farmaci in grado di bloccare EGFR e\/o TK.
\nToxic side effects to the skin occur in almost all individuals undergoing these therapies and, in some cases, levels of toxicity can reach up to grades three or four, meaning that the entire treatment course must be discontinued.
\nThese are side effects that cannot be prevented or avoided. It is therefore important that they are addressed with specific treatments to reduce any discomfort or suffering for the individual so that they can complete the full course of cancer therapy.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n

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Indice<\/p>\n<\/span><\/div>\n