{"id":3311,"date":"2023-08-10T14:03:42","date_gmt":"2023-08-10T12:03:42","guid":{"rendered":"https:\/\/dermaclub.it\/uncategorized\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/"},"modified":"2026-01-05T15:27:50","modified_gmt":"2026-01-05T14:27:50","slug":"cortisone-in-dermatology-when-it-becomes-a-medical-issue","status":"publish","type":"post","link":"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/","title":{"rendered":"Cortisone in Dermatology: controversies and side effects"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indice<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#What_is_cortisone\" >What is cortisone?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#How_does_cortisone_work\" >How does cortisone work?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#What_are_the_side_effects_of_cortisone\" >What are the side effects of cortisone?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#The_use_of_cortisone_in_dermatology\" >The use of cortisone in dermatology<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Side_effects_of_topical_cortisone\" >Side effects of topical cortisone<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Pharmacological_potency_of_synthetic_corticosteroids_on_the_skin\" >Pharmacological potency of synthetic corticosteroids on the skin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Cortisone_dependency\" >Cortisone dependency<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Tachyphylaxis\" >Tachyphylaxis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Rebound\" >Rebound<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Withdrawal\" >Withdrawal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Red_skin_syndrome_RSS\" >Red skin syndrome (RSS)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Systemic_cortisone_treatments\" >Systemic cortisone treatments<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Topical_steroid_withdrawal_TSW\" >Topical steroid withdrawal (TSW)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Rebound_and_withdrawal_during_TSW\" >Rebound and withdrawal during TSW<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Duration_of_rebound_and_withdrawal\" >Duration of rebound and withdrawal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#How_to_assist_an_individual_in_rebound_and_withdrawal\" >How to assist an individual in rebound and withdrawal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#The_exudative_phase\" >The exudative phase<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/cortisone-in-dermatology-when-it-becomes-a-medical-issue\/#Red_skin_syndrome\" >Red skin syndrome<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_is_cortisone\"><\/span><b>What is cortisone?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;2534&#8243; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Cortisone, and corticosteroids in general, are a group of natural and synthetic hormones similar to cortisol, which is the human hormone produced by the adrenal gland. As they have notable anti-inflammatory and immunosuppressive properties, they are widely used in medicine.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_does_cortisone_work\"><\/span><b>How does cortisone work?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Corticosteroids are naturally produced by the adrenal gland. They can affect the function of any organ or system such as the heart, bones, skin function and muscles, as well as the immune, endocrine and nervous systems. Corticosteroids act by altering carbohydrate, protein and fat metabolism.<\/p>\n<p>The main properties of corticosteroids are:<\/p>\n<ul>\n<li>anti-inflammatory<\/li>\n<li>immunosuppressive<\/li>\n<li>antiproliferative<\/li>\n<li>vasoconstrictor<\/li>\n<\/ul>\n<p>Corticosteroids are anti-inflammatory as they block the mediators of inflammation and trigger the formation of anti-inflammatory mediators.<br \/>\nThe immunosuppressive function is related to the direct inhibitory action on T lymphocyte activity.<br \/>\nCorticosteroids proliferative function is exerted by directly blocking DNA synthesis and, thus, cell turnover.<br \/>\nFinally, corticosteroids are vasoconstrictors due to the inhibition of vasodilator inflammation mediators such as histidine.<br \/>\nThe above functions are harnessed extensively in medicine through balancing doses and varying route of administration.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_are_the_side_effects_of_cortisone\"><\/span><b>What are the side effects of cortisone?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]Cortisone has many side effects that are mostly related to dosage and duration of administration.<\/p>\n<ul>\n<li>Neuropsychiatric: at a low dosage, cortisone may result in \u201csteroidal euphoria\u201d. Instead, at high dosage, it will induce anxiety, depression and symptoms of psychosis (steroid-induced psychosis)<\/li>\n<li>Cardiovascular: increased fluid retention with hypertension mainly due to increased sodium retention function<\/li>\n<li>Metabolic: inhibition of protein synthesis and increased protein catabolism can result in developmental delay (young children) and osteoporosis (bone fragility). It can also cause changes in fat metabolism, with fat accumulating in the face (\u201cmoon face\u201d) and back. Cortisone can also cause increased sweating and sebaceous secretion.<\/li>\n<li>Endocrine: due to the overproduction of glucose from amino acids hyperglycemia, insulin resistance and diabetes can occur<\/li>\n<li>Skeletal: risk of osteoporosis due to inhibition from calcium uptake into the bones<\/li>\n<li>Gastrointestinal: increased gastric acidity with risk of ulceration<\/li>\n<li>Ocular: increased eye pressure, retinal detachment, early cataracts<\/li>\n<li>Infectious: due to immunosuppression, risk of infection or the reactivation of a latent infection (TB, hepatitis C)<\/li>\n<li>Pregnancy: increased risk of teratogenicity (fetal malformation)<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_single_image image=&#8221;2536&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_use_of_cortisone_in_dermatology\"><\/span><strong>The use of cortisone in dermatology<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Topical cortisone is often prescribed for inflammatory dermatologic conditions and is applied directly onto injured skin. Cortisone is used in cases of:<\/p>\n<ul>\n<li>Psoriasis<\/li>\n<li>Atopic dermatitis<\/li>\n<li>Seborrheic dermatitis<\/li>\n<li>Rosacea<\/li>\n<li>Lichen planus<\/li>\n<li>Dyshidrosis<\/li>\n<li>Itchy dermatitis<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;2537&#8243; alignment=&#8221;center&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]By exerting its anti-inflammatory, antiproliferative and vasoconstrictive properties, cortisone induces a rapid anti-dermatitis respositive action.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Side_effects_of_topical_cortisone\"><\/span><strong>Side effects of topical cortisone<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]In addition to other more beneficial functions, when applied to the skin, cortisone can provoke side-effects that are particularly negative as they can cause changes in the skin and\/or cause other conditions. These include:<\/p>\n<ul>\n<li>atrophy<\/li>\n<li>telangiectasias<\/li>\n<li>stretch marks<\/li>\n<li>hair growth<\/li>\n<li>petechial purpura<\/li>\n<li>perioral dermatitis<\/li>\n<li>rosacea<\/li>\n<li>acne<\/li>\n<li>hyper- or hypo-pigmentation<\/li>\n<li>sensitivity to light<\/li>\n<li>tumor degeneration<\/li>\n<li>spread of infections<\/li>\n<\/ul>\n<p>For these reasons, among others, the use of topical cortisone must be used sparingly over a very short period. Another limitation is the pharmacological potency of the cortisone used.[\/vc_column_text][vc_single_image image=&#8221;2535&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Pharmacological_potency_of_synthetic_corticosteroids_on_the_skin\"><\/span><b>Pharmacological potency of synthetic corticosteroids on the skin<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Pharmacological potency is one of the parameters used to evaluate the toxicity of various corticosteroids on the skin. This information can then be used to select the most appropriate corticosteroid to use and for how long it should be administered.<\/p>\n<ul>\n<li>Very high potency: clobetasol propionate; betamethasone dipropionate<\/li>\n<li>High potency: fluocinonide; halcinonide; mometasone<\/li>\n<li>Medium-high potency: fluticasone; triamcinolone<\/li>\n<li>Medium potency: mometasone fluoride; betamethasone valerate<\/li>\n<li>Medium-low potency: alclometasone dipropionate; desonide<\/li>\n<li>Low potency: hydrocortisone<\/li>\n<\/ul>\n<p>As a rule of thumb, the greater pharmacological potency, the greater toxicity, meaning that the duration of treatment should therefore be limited and vice versa.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;2538&#8243; alignment=&#8221;center&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Cortisone_dependency\"><\/span><b>Cortisone dependency<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]A major and, likely, the most dreaded side effect of cortisone is addiction. When applied to the skin, cortisone basically acts just as a drug would. Cortisone dependency &#8211; whereby the individual can no longer live without it &#8211; quickly sets in, sometimes as early as within a week of treatment.<br \/>\nThis dependency becomes very evident when the individual tries to stop cortisone and a rebound occurs.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Tachyphylaxis\"><\/span><b>Tachyphylaxis<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Tachyphylaxis is something that can happen with all drugs. It occurs when the body develops a reduced response to a drug, which means it will likely require a higher dose or more frequent administrations to achieve the same effect. In other words, an individual who has started applying cortisone once in a while to control dermatitis, will soon realize that in order to achieve the same result, they must continually increase the frequency of application (or the dose applied). Tachyphylaxis immediately leads to toxicity.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Rebound\"><\/span><b>Rebound<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Viene detto Rebound il fenomeno per cui dopo la sospensione del cortisone si \u200b\u200bRebound refers to the phenomenon whereby, after discontinuing cortisone, there is a sudden worsening of the dermatitis for which the product had been prescribed. The severity of the rebound will relate to the potency of the cortisone used and the duration of use. Without the correct guidance, rebound is the main reason why an individual remains dependent on cortisone.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Withdrawal\"><\/span><b>Withdrawal<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]For many individuals, the discontinuation of cortisone not only causes rebound (worsening of original dermatitis) but also provokes more general malaise with symptoms including fatigue, agitation, insomnia, loss of appetite, sweating and tremors, etc. In other words, cortisone withdrawal is not dissimilar to that of other drugs and, similarly, the individual needs help and support to overcome it.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;2533&#8243; alignment=&#8221;center&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Red_skin_syndrome_RSS\"><\/span><b>Red skin syndrome (RSS)<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Red skin syndrome (RSS) can creep up in those who have been treating dermatitis with either topical or systemic cortisone for some time.<br \/>\nAt first, RSS appears to be a simple worsening of the dermatitis, for which the individual applies more cortisone. Suddenly, all or most of the skin will become bright red, often accompanied by exudation, the formation of cuts, intense itching and a strong burning sensation. Alongside these symptoms, the patient will feel general malaise, including agitation, feeling cold, exhaustion and fever. It is a severe, acute condition where the skin can become quickly infected and the infection transmitted internally. The individual will often require hospitalization to monitor and maintain vital parameters.<br \/>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><strong>Systemic cortisone treatments<br \/>\n<\/strong><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;2540&#8243; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Cortisone can be prescribed systemically to treat dermatitis and is available in either tablet or liquid form. Sometimes, systemic and topical treatment can be used simultaneously.<br \/>\nSystemic cortisone can cause the same adverse reactions on the skin and can worsen dermatitis in the same way that topical treatments do, but will provoke these side-effects much more quickly.<br \/>\nIn addition, if the individual is in topical steroid withdrawal, but is prescribed systemic cortisone for other reasons, their dependence on cortisone will re-emerge and they will need to begin a course of treatment to overcome this dependency all over again.<br \/>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Topical_steroid_withdrawal_TSW\"><\/span><b>Topical steroid withdrawal (TSW)<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Withdrawal from cortisone causes varying degrees of skin distress. The severity of distress caused will partly depend on the duration of cortisone use, the extent to which it was applied and the potency used.<br \/>\nAs soon as the dermatologist diagnoses cortisone dependency, the goal should be to immediately assist the individual in overcoming rebound and withdrawal in order to reduce the risk of red skin syndrome, which could appear at any time.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Rebound_and_withdrawal_during_TSW\"><\/span><strong>Rebound and withdrawal during TSW<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]After cortisone withdrawal, the onset of withdrawal symptoms will likely appear within seven to ten days. This is due to the fact that the skin retains any residual cortisone and uses it up during this time period.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Duration_of_rebound_and_withdrawal\"><\/span><b>Duration of rebound and withdrawal<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]There is considerable variability in the duration of rebound and withdrawal due to many factors such as the type of dermatitis for which cortisone was used, the potency of cortisone used, extent of application site, and the duration of application. In general, symptoms of rebound and withdrawal last for at least one month and can sometimes persist for over a year.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;2539&#8243; img_size=&#8221;200X200&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_to_assist_an_individual_in_rebound_and_withdrawal\"><\/span><b>How to assist an individual in rebound and withdrawal<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]The first obligation of the dermatologist is to convince the individual to go through rebound and withdrawal. To do so, it is important that the individual fully understands that continuing with cortisone is dangerous and will cause greater problems in the future. It is crucial to explain to them that, once withdrawal is over, the dermatitis can finally be cured and sent into remission. It is crucial to understand that during the acute crisis period of the rebound phase, the skin will not tolerate the application of any product. Any attempt to apply products to the skin is followed by a further worsening of the condition. Similarly, wetting or washing the area with dermatitis must be suspended, as this will also stress the skin. To at least partially reduce itchiness, control exudation and prevent infection, apply moist cold compresses in potassium permanganate.<br \/>\nIf the dermatitis is extensive, potassium permanganate solution should be used to \u2018dry\u2019 wash the entire body, including the head.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_exudative_phase\"><\/span><b>The exudative phase<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]The phase begins upon the discontinuation of cortisone and is characterized by the exudation of serum droplets, a sticky liquid that emerges from the skin. The duration of this phase is particularly variable and unpredictable, but for however long it lasts, it\u2019s important to use moist cold compresses with potassium permanganate solution in order to keep the body clean. In addition to preventing skin infection in this delicate phase, this disinfectant has astringent properties that help limit and stop exudation altogether.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;2527&#8243; img_size=&#8221;200*200&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Red_skin_syndrome\"><\/span><b>Red skin syndrome<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221;]Once the exudative phase is over, red skin syndrome follows, causing the skin to become completely red. At the same time, symptoms of intense burning accompany feelings of cold due to heat loss from the inflamed skin.<br \/>\nAt this point, the only product that is proven to be tolerated and help the patient toward healing is <a href=\"https:\/\/www.mostskincare.com\/en\/shop\/dermatology-line\/peg-balm\/\">PEG Ointment<\/a> with allantoin.<br \/>\nPEG Ointment originated as a healing agent for ulcers and wounds but, in DermaClub&#8217;s experience, it is the only product that can be applied to soothe the skin during rebound and withdrawal. In the more acute stages of rebound and withdrawal, even PEG Ointment will not be tolerated. If this occurs, wait a few days without applying any product to the affected areas before trying again. Repeat until PEG Ointment is not only tolerated, but is providing clear benefit to the individual.<br \/>\nBy continuing with \u2018dry\u2019 washes and PEG Ointment, the withdrawal phase will come to a close. From there, the treatment of the original dermatitis can begin using non-corticosteroid products that should have been used from the start.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] What is cortisone? [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;2534&#8243; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Cortisone, and corticosteroids in general, are a group of natural and synthetic hormones similar to cortisol, which is<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":2541,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52],"tags":[],"class_list":["post-3311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-skin-diseases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.1 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cortisone in dermatology: when it is a medical disease<\/title>\n<meta name=\"description\" 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