{"id":3397,"date":"2023-08-07T09:50:16","date_gmt":"2023-08-07T07:50:16","guid":{"rendered":"https:\/\/dermaclub.it\/uncategorized\/tretinoin-a-dermatological-solution\/"},"modified":"2024-11-22T11:21:20","modified_gmt":"2024-11-22T10:21:20","slug":"tretinoin-a-dermatological-solution","status":"publish","type":"post","link":"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/","title":{"rendered":"Tretinoin: a dermatological solution"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indice<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/#Retinol_vitamin_A1\" >Retinol (vitamin A1)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/#The_role_of_vitamin_A\" >The role of vitamin A<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/#How_vitamin_A_works\" >How vitamin A works<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/#Why_retinol_applied_to_the_skin_doesnt_work\" >Why retinol applied to the skin doesn\u2019t work<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/#From_retinoids_to_retinoic_acid_tretinoin\" >From retinoids to retinoic acid (tretinoin)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/#Retinoic_acid_and_the_skin\" >Retinoic acid and the skin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/#How_to_avoid_retinoic_acid_toxicity\" >How to avoid retinoic acid toxicity<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/#Why_tretinoin_should_be_used_as_a_solution_and_not_as_a_cream\" >Why tretinoin should be used as a solution, and not as a cream<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/dermaclub.it\/en\/topical-therapy\/tretinoin-a-dermatological-solution\/#Prescription_for_tretinoin_solution\" >Prescription for tretinoin solution<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Retinol_vitamin_A1\"><\/span><b>Retinol (vitamin A1)<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]<span style=\"font-weight: 400;\">Retinol (vitamin A1) is a vitamin compound within the vitamin A family, created by the body using the beta carotene in our diet. Beta carotene is contained in red and orange vegetables and fruits, such as tomatoes, carrots and oranges, etc., and in animal meats, especially in liver. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">After intestinal absorption, the beta carotene is transported to the liver where it is converted into retinol molecules. These individual retinol molecules are then stored in specialized cells within the liver. These cells, known as HSCs, also contain lipids and vitamin A. <\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_role_of_vitamin_A\"><\/span><strong>The role of vitamin A<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]<span style=\"font-weight: 400;\">Vitamin A is an important nutrient for vision, tissue growth and differentiation, cell division, reproduction, and immunity.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vitamin A deficiency can cause problems including skin and eye dryness, intestinal disorders and infertility.<\/span>[\/vc_column_text][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_vitamin_A_works\"><\/span><b>How vitamin A works<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]<span style=\"font-weight: 400;\">Vitamin A acts within cells by stimulating both cell reproduction and protein synthesis. To do this, it needs an entry key to unlock the cell membrane, without which it is unable to penetrate cells. This key comes in the form of a specific protein synthesized by the liver called retinol binding protein (RBP). The RBP complex is recognised by the receptor on the cell membrane, which then allows vitamin A to enter the cell and perform its role as a nutrient.   <\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Why_retinol_applied_to_the_skin_doesnt_work\"><\/span><b>Why retinol applied to the skin doesn\u2019t work<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]There are a huge number of retinol-based cosmetic products on the market, from creams, to lotions, to oils and balms. There is also a popular belief that these products help the skin to regenerate and perform better, however, this is simply untrue and these products do not work. This is because retinol, as it appears in cosmetic products, cannot penetrate the skin cells as there is no RBP present, a protein of which occurs exclusively in the liver.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"From_retinoids_to_retinoic_acid_tretinoin\"><\/span><b>From retinoids to retinoic acid (tretinoin)<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_column_text]Within the body, retinol is first transformed into retinaldehyde, and finally into retinoic acid. Even though there is less of it produced compared to retinol, retinoic acid has an important function in cell maturation and differentiation of the even deeper epidermal cells. Unlike retinol, it does not need any binding protein to penetrate the inside of a cell because a specific receptor for retinoic acid already exists on the cell membrane.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_images_carousel images=&#8221;162,160&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Retinoic_acid_and_the_skin\"><\/span><b>Retinoic acid and the skin<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]When applied to the skin, retinoic acid immediately begins stimulating cell regeneration by accelerating turn over and differentiating damaged or deviated cells. Therefore, retinoic acid can be used in many pathological situations within dermatology:<\/p>\n<ul>\n<li>Acne &gt; prevents hyperkeratosis of follicles<\/li>\n<li>Photoaging &gt; differentiates sun-damaged cells into normal cells<\/li>\n<li>Melasma &gt; increases cell turnover by rapidly eliminating excess melanin<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;158&#8243; img_size=&#8221;400X304&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;159&#8243; img_size=&#8221;400X304&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_to_avoid_retinoic_acid_toxicity\"><\/span><b>How to avoid retinoic acid toxicity<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]<span style=\"font-weight: 400;\">When too much retinoic acid is administered to the skin, it can cause toxicity that results in redness, dryness and itching. This is referred to as retinoic dermatitis. Studies have found that one administration of tretinoin changes cell behavior for up to four days. This means that, if the tretinoin is applied daily or even several times per day, the cells will go into toxicity. The correct dose of tretinoin that will still deliver results is one or two non-consecutive applications per week.  <\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Why_tretinoin_should_be_used_as_a_solution_and_not_as_a_cream\"><\/span><b>Why tretinoin should be used as a solution, and not as a cream<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]<span style=\"font-weight: 400;\">In the three main conditions for which tretinoin is used, cream is often not the right mode of application: in cases of acne, the cream penetrates the follicles which inhibits the release of comedones; in cases of photodamaged skin and melasma, cream slows down desquamation and cell renewal. Instead, tretinoin solution gives a far better result and is easier to dose, as the user can precisely calculate the number of drops to be applied to the skin. <\/span>[\/vc_column_text][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Prescription_for_tretinoin_solution\"><\/span><b>Prescription for tretinoin solution<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]<span style=\"font-weight: 400;\">Tretinoin 0.05 %<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Propylene Glycol 40 %<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ethyl Alcohol (96%) 59.9 %<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AlphaTocopherol 0.05%<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Stored in a dark 50 ml bottle with a dropper cap. <\/span>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] Retinol (vitamin A1) [\/vc_column_text][vc_column_text]Retinol (vitamin A1) is a vitamin compound within the vitamin A family, created by the body using the beta carotene in our<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":2409,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-3397","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topical-therapy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.1 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Tretinoin: a dermatological solution<\/title>\n<meta name=\"description\" content=\"Retinoic Acid or Tretinoin in topical solution is well suited for the treatment of Acne, Photodamage and Melasma without giving toxicity\" \/>\n<meta name=\"robots\" content=\"index, follow, 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