{"id":3599,"date":"2023-09-21T15:35:59","date_gmt":"2023-09-21T13:35:59","guid":{"rendered":"https:\/\/dermaclub.it\/uncategorized\/athletes-foot-pharmacological-treatments-and-alternative-remedies\/"},"modified":"2026-04-01T16:58:32","modified_gmt":"2026-04-01T14:58:32","slug":"athletes-foot-pharmacological-treatments-and-alternative-remedies","status":"publish","type":"post","link":"https:\/\/dermaclub.it\/en\/podology\/athletes-foot-pharmacological-treatments-and-alternative-remedies\/","title":{"rendered":"Athlete\u2019s foot: pharmacological treatments and alternative remedies"},"content":{"rendered":"

[vc_row][vc_column width=”1\/2″][vc_single_image image=”2976″ img_size=”large” alignment=”center”][\/vc_column][vc_column width=”1\/2″][vc_column_text]Athlete\u2019s foot can affect the skin and nails, both of which can be treated with antifungal systemic and local pharmaceuticals or non-pharmaceuticals.
\nAntifungal pharmaceuticals break down the fungus\u2019 cell wall which protects it from the external environment.
\nDrugs belonging to the terbinafine group block the fungus\u2019 transition from the squalene to the squalene epoxide, while drugs in the azoles group block the transition from lanosterol to ergosterol.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]In order to work, these drugs have to wait for the fungus to reduplicate and for the fungal cell walls to form, meaning that they can be classified as fungistatic pharmaceuticals.
\nAzoles are synthetic compounds that are classified as either imidazoles or triazoles.
\nImidazoles include pharmaceuticals like ketoconazole, miconazole and clotrimazole.
\nTriazoles include drugs such as itraconazole, fluconazole, voriconazole, and posaconazole.
\nTerbinafine is a synthetic allylamine that inhibits the enzyme\u2019s squalene epoxidase.
\nThis causes the accumulation of excess squalene that is toxic to the microorganism.
\nAnother drug active against dermatophytes but with a different mechanism of action from the previous ones is Griseofulvin.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=”2\/3″][vc_column_text]Griseofulvin is an insoluble fungistatic drug derived from a species of penicillium that tackles dermatophytes in a slightly different way.
\nWhile its exact mechanisms aren\u2019t well known, griseofulvin appears in the newly formed stratum corneum by binding to keratins to stop the proliferation of dermatophytes.
\nFor the treatment of onychomycosis or athlete’s foot, oral pharmaceuticals are often prescribed, as local administration (e.g. creams) often cannot properly penetrate the nail plate.[\/vc_column_text][\/vc_column][vc_column width=”1\/3″][vc_single_image image=”2977″ img_size=”large” alignment=”center”][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n

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Indice<\/p>\n<\/span><\/div>\n