{"id":3629,"date":"2024-06-18T16:06:32","date_gmt":"2024-06-18T14:06:32","guid":{"rendered":"https:\/\/dermaclub.it\/uncategorized\/neurofibromatosis-nf\/"},"modified":"2024-12-06T14:52:20","modified_gmt":"2024-12-06T13:52:20","slug":"neurofibromatosis-nf","status":"publish","type":"post","link":"https:\/\/dermaclub.it\/en\/skin-diseases\/neurofibromatosis-nf\/","title":{"rendered":"Neurofibromatosis (NF)"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indice<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/neurofibromatosis-nf\/#Description\" >Description<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/neurofibromatosis-nf\/#Causes\" >Causes<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/neurofibromatosis-nf\/#Symptoms\" >Symptoms<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/neurofibromatosis-nf\/#Diagnosis\" >Diagnosis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/dermaclub.it\/en\/skin-diseases\/neurofibromatosis-nf\/#Treatment\" >Treatment<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Description\"><\/span><strong>Description<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Neurofibromatoses are a group of hereditary genetic syndromes caused by gene mutations.<br \/>\nThere are three recognized types of NF:<\/p>\n<ol>\n<li>Neurofibromatosis type 1 (NF1), also called von Recklinghausen disease<\/li>\n<li>Neurofibromatosis type 2 (NF2)<\/li>\n<li>Schwannomatosis (SWN)<\/li>\n<\/ol>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Causes\"><\/span><strong>Causes<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]NF1, the most common form, results from a mutation in a gene on chromosome 17q11.2. This gene produces neurofibromin 1, a protein crucial for normal nerve growth. Its absence leads to excessive nerve growth, causing the neurofibromas characteristic of the condition.<br \/>\nNF1 affects approximately 1 in 3,000 individuals. It is often familial, with 50% of cases having a documented family history, while the rest arise from new mutations.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Symptoms\"><\/span><strong>Symptoms<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]NF1 manifests in diverse ways, involving the skin, eyes, and nervous system.<br \/>\nKey signs include:<\/p>\n<ul>\n<li><strong>Caf\u00e9-au-lait spots<\/strong>: present in 95% of NF1 patients, these patches typically appear at birth or during the first year of life. <img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2187 size-thumbnail alignright\" src=\"https:\/\/dermaclub.it\/wp-content\/uploads\/2024\/06\/neurofibromatosi-1-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" srcset=\"https:\/\/dermaclub.it\/wp-content\/uploads\/2024\/06\/neurofibromatosi-1-300x200.jpg 300w, https:\/\/dermaclub.it\/wp-content\/uploads\/2024\/06\/neurofibromatosi-1-500x334.jpg 500w, https:\/\/dermaclub.it\/wp-content\/uploads\/2024\/06\/neurofibromatosi-1-768x512.jpg 768w, https:\/\/dermaclub.it\/wp-content\/uploads\/2024\/06\/neurofibromatosi-1-112x75.jpg 112w, https:\/\/dermaclub.it\/wp-content\/uploads\/2024\/06\/neurofibromatosi-1-480x320.jpg 480w, https:\/\/dermaclub.it\/wp-content\/uploads\/2024\/06\/neurofibromatosi-1.jpg 1000w\" sizes=\"auto, (max-width:767px) 300px, 300px\" \/>By childhood, most affected individuals have at least six spots, usually over 5 mm in size.  <\/li>\n<li><strong>Freckling<\/strong>: small, caf\u00e9-au-lait-colored freckles often appear in the armpits, groin, or under the breasts.<\/li>\n<li><strong>Neurofibromas<\/strong>: these benign nerve tumors, most often cutaneous, typically emerge around puberty. They can range in size from small nodules to bean-sized or larger growths and are often painless. Subcutaneous neurofibromas, found along larger peripheral nerves, may cause pain or functional difficulties.      <\/li>\n<li><strong>Lisch nodules<\/strong>: Yellow-brown, raised nodules on the iris develop around puberty, appearing in nearly all adults with NF1 without affecting vision. <\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diagnosis\"><\/span><strong>Diagnosis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]NF1 diagnosis is typically based on clinical findings. A genetic test, performed using a blood sample, can confirm the NF1 gene mutation in most cases. <\/p>\n<p><strong>Progression<\/strong><\/p>\n<p>Most NF1 cases are limited to aesthetic concerns caused by numerous cutaneous neurofibromas. However, in some individuals, optic pathway gliomas or brain gliomas may require surgical intervention. Malignant peripheral nerve sheath tumors are rare complications.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Treatment\"><\/span><strong>Treatment<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]Historically, NF1 treatments focused on surgical removal of neurofibromas for aesthetic, functional, or oncological reasons.<br \/>\nRecently, the FDA approved Selumetinib (Koselugo), a biologic drug targeting MEK-1\/2 enzymes, which helps control nerve cell proliferation in NF1 patients. <strong>Neurofibromatosis Type 2 (NF2)<\/strong><br \/>\nNF2 is characterized by bilateral vestibular schwannomas (nerve sheath tumors), causing hearing loss, vertigo, headaches, or facial weakness due to nerve compression. <strong>Schwannomatosis<\/strong><br \/>\nThis subtype involves multiple schwannomas on cranial, spinal, or peripheral nerves. The initial symptom is often chronic, severe pain, with other symptoms varying depending on tumor location.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] Description [\/vc_column_text][vc_column_text]Neurofibromatoses are a group of hereditary genetic syndromes caused by gene mutations. There are three recognized types of NF: Neurofibromatosis type 1 (NF1), also<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":3039,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52],"tags":[],"class_list":["post-3629","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-skin-diseases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.1 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Neurofibromatosis (NF)<\/title>\n<meta name=\"description\" content=\"Neurofibromatosis is a group of inherited genetic syndromes caused by a mutation in a gene.Three forms of NF are recognised...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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